Differential effects of ethanol in the nucleus accumbens shell of alcohol-preferring (P), alcohol-non-preferring (NP) and Wistar rats: A proteomics study
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چکیده
منابع مشابه
Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats.
The current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats. Rats self-trained on a standard two-lever operant paradigm to administer either water-water, EtOH (15% v/v)-water, or saccharin (SAC; 0.0125% g/v)-water. Animals were killed 24 h after the last operant...
متن کاملProteomics and metabolomics analysis of hepatic mitochondrial metabolism in alcohol-preferring and non-preferring rats
Alcohol preference induced tolerance in humans and animals when their bodily functions adapt to compensate for the disruption caused by alcohol consumption. This was thought to be an important component of the genetic predisposition to alcoholism. To investigate the underlying mechanisms of hepatic metabolic tolerance during alcohol preference, the alcohol preferring and alcohol non-preferring ...
متن کاملA comparison of the reinforcing efficacy of alcohol in alcohol-preferring (P) and alcohol-nonpreferring (NP) rats.
A key feature of the selective breeding program that produced alcohol-preferring (P) and alcohol-nonpreferring (NP) rats is that the alcohol was mixed with water. However, humans typically drink sweetened or palatably flavored alcohol. The experiments in this study tested whether the differences in P and NP rats generalize to sweetened alcohol. In Experiment 1, P rats drank more alcohol than NP...
متن کاملFat-preferring rats consume more alcohol than carbohydrate-preferring rats.
Rats with a genetic preference for alcohol (ETOH) have been found to consume more dietary fat then ETOH nonpreferring rats. We therefore hypothesized that rats selected on the basis of fat and carbohydrate (CHO) preferences would differ in ETOH intake. Patterns of macronutrient self-selection were determined by allowing rats to select diets from separate sources of CHO, fat and protein. Subsequ...
متن کاملD1 receptors in the nucleus accumbens-shell, but not the core, are involved in mediating ethanol-seeking behavior of alcohol-preferring (P) rats.
Clinical and preclinical research suggest that activation of the mesolimbic dopamine (DA) system is involved in mediating the rewarding actions of drugs of abuse, as well as promoting drug-seeking behavior. Inhibition of DA D1 receptors in the nucleus accumbens (Acb) can reduce ethanol (EtOH)-seeking behavior of non-selective rats triggered by environmental context. However, to date, there has ...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 2009
ISSN: 0091-3057
DOI: 10.1016/j.pbb.2008.12.019